Diabetes and Stem Cell Therapy

Diabetes mellitus (DM), or as it’s more commonly known diabetes (type 1 and type 2), is a disease characterised by an excess of blood glucose, or blood sugar, which builds up in the bloodstream when your body isn’t able to adequately process the sugar in food.

Diabetes is one of the most widespread diseases and for many, this means living with daily insulin injections and the possibility of long-term health damage.

What is type one diabetes?

Type 1 diabetes is an autoimmune disease that results from T cell autoimmunity mediated destruction of the vast majority of insulin-producing pancreatic β-cells. Therefore, the development of new therapies to control T cell autoimmunity and to preserve the remaining β-cell function is of great significance in managing patients with type 1 diabetes. Those diagnosed with T1DM (type 1 diabetes mellitus) are relying on exogenous insulin.

Adipose tissue derived mesenchymal stem cells have been shown in many studies as potential cure for T1DM, which could not only address the need for β-cell replacement but also the regulation of the autoimmune response to cells which produce insulin. Mesenchymal stem cells are able to control T cell autoimmunity.

In both forms of diabetes, unless treated, blood sugar will rise uncontrollably, and over time can lead to complications such as cardiovascular, liver and kidney disease (diabetic nephropathy), as well as circulatory problems that may require limb amputation, vision loss, blindness (diabetic retinopathy), and nerve damage (diabetic neuropathy).

How is type one diabetes treated at the moment?

People with type 1 diabetes need to have their blood sugar levels tested several times a day and inject them selves  insulin when it is needed. Unfortunately, it can still be hard to keep the blood sugar level normal even with regular injections. Over time, a high level of blood sugar can cause serious damage to the heart, eyes, blood vessels, kidneys and nerves, whilst injecting too much insulin can lead to a level that’s too low (hypoglycaemia) which can be fatal.

It is possible to treat T1DM with organ transplantation (islet cells or even a whole pancreas) to the patient from donor to enable the body to regain control of blood sugar levels so that insulin injections are no longer needed. However islet transplantation is not very common, because the whole pancreas transplants involve major surgery and carry significant risk. Also, the number of donors is heavily outweighed by the demand and transplants require the immune system to be suppressed so that the new ‘alien’ organ is not rejected. Immunity suppressing drugs leave the recipient vulnerable to infections and often have side effects.

Diabetes stem cells treatment

One of the biggest problems faced by islet transplantation is the lack of donors. Instead of using donor cells, own stem cells can be used in diabetes therapy, bypassing all the complications, rejections and side effects.

Research has shown that stem cells present in the patient’s pancreas are able to make new beta cells. Beta cell progenitors have been found in the pancreas of both rodents and humans; progenitor cells have some stem cell properties and can self-renew (duplicate themselves) indefinitely. The stem cells from the patient’s own adipose tissue or bone marrow can ‘re-educate’ the immune system so that it no longer attacks the beta cells. The new beta cells are able to sense blood sugar levels and react accordingly.

Clinical trials inserting mesenchymal stem cells into type 1 diabetes patients take advantage of two assets these cells possess. Firstly, they have the regenerative potential to repair beta cells, and secondly they can modulate the immune system by inhibiting the responses that lead to the autoimmune attack on pancreatic beta cells.

Stem cells are a part of a human body naturally, and they have the unique ability to find and repair the place of damage inside the system. For results to fully develop, it usually takes up to four months after the stem cells are injected into human organism during treatment. In the course of that time, a patient notices continuous new improvements. Since these stem cells come from patient’s own body, there is also no risk of rejection or side effects. The whole procedure is very quick, painless, simple and safe, and it is completed within only few hours. This approach promotes beta cell function, thereby reducing or eliminating the requirement for exogenous insulin.

Cell Therapy in Kuala Lumpur

CelesticaLife Clinic has developed the Adult Autologous Stem Cell Therapy program to treat a variety of conditions, one of them being diabetes type 1. Our program is designed to suit your unique and personal needs. It is a safe process where blood cells are isolated, harvested, processed, activated by Tithon Biotech’s unique patented technology and re-infused back into your own body. We do not use plant and animal products nor do we introduce harmful chemical products as part of our cell therapy process.

At CelesticaLife, our team members are expertly trained to deliver a professional service you can trust. Their main goal is to create a comfortable environment for you to heal and rejuvenate your body through the treatment, lifestyle counselling and aesthetics.

Contact us for mire information regarding our treatment packages.